South Dakota First Capital is a venture capital firm launched in October 2024 that backs pre-seed to Series A companies in South Dakota and surrounding states, with U.S. seed activity in health technology. It focuses on B2B and B2C software, medical devices, food tech, ag tech, energy, mining tech, manufacturing tech, gov tech, supply chain/logistics, and cybersecurity, typically investing $250,000 to $1,000,000 per company.