Skyline Ventures

Skyline Ventures is a Palo Alto, California–based venture capital firm founded in 1997 that focuses on early-stage and growth investments primarily in healthcare and life sciences, including small molecule and protein therapeutics, medical devices, diagnostics, and enabling technologies for drug discovery and life science research. The firm typically makes institutional venture investments with initial checks often in the mid-single to low-double-digit millions, aiming to lead or co-lead rounds and taking active board roles to support strategic development. Skyline evaluates opportunities based on scientific rigor, market potential and team quality, and its portfolio has included companies across biotechnology and medical innovation. Headquartered in the U.S., it has backed ventures predominantly in the San Francisco Bay Area and other U.S. regions. The firm’s investment history includes multiple funds and portfolio exits in life sciences and healthcare fields.