Regenstrief Foundation is an independent non-profit foundation based in Indianapolis, Indiana. Established in 1967 by industrialist Samuel N. Regenstrief and his wife Myrtie Regenstrief, the foundation provides grants for innovative research directed towards improving the efficiency, quality, and accessibility of health care. The assets of the foundation are managed by the board of directors.Regenstrief Foundation's investment portfolio is valued at $180.03 million, with investments in domestic and international equity, fixed income, private equity, and cash.