Helena is a Los Angeles- and New York-based venture capital firm backing thematic, technology-driven U.S. companies from early to later-stage rounds. It invests across AI and machine learning, deep tech, energy, climate, healthtech, biotechnology, sustainability, robotics, defense and infrastructure, with additional activity in materials, industrial technology, manufacturing and automation. Helena has acted as a lead investor, and portfolio companies include Twin Health, Phaidra and Commonwealth Fusion Systems.