CrossLayer Capital is a blockchain-focused fund-of-funds backing crypto and web3 venture managers. The firm focuses on managers investing across decentralized infrastructure, digital assets and blockchain-native founder networks, with blockchain manager investing activity since 2018. Portfolio managers include 1confirmation, 1kx, Archetype, Castle Island, CoinFund, Dragonfly, Framework Ventures, Multicoin Capital and Variant. It is most relevant for crypto and web3 fund managers seeking LP capital or fund-level co-investment rather than founders raising direct startup rounds.