3x5 Partners

3x5 Partners is a U.S.-based venture capital firm founded in 2011 and headquartered in Portland, Oregon. The firm focuses on early-stage and growth investments in healthcare and climate-related sectors, including biotechnology, medical devices, energy, water, food systems, and environmental technologies. It typically invests in capital-intensive companies with long development cycles and high technical or scientific complexity. The firm is known for leading early institutional rounds and taking active board roles, often deploying relatively large checks per company compared to traditional early-stage VCs. Its investment strategy emphasizes patient capital, long-term company building, and backing solutions addressing systemic health and climate challenges.