Tobacco Settlement Endowment Trust (TSET) is a government agency based in Oklahoma City, Oklahoma. Established in 2000, TSET has focused funding on reducing Oklahoma's leading causes of preventable death, tobacco use, and obesity, in order to reduce cancer and cardiovascular disease. As a state grantmaking trust, TSET funds prevention, research, and emerging opportunities to improve the health of every Oklahoman. The assets of the agency are managed by the executive management team.Tobacco Settlement Endowment Trust's investment portfolio is valued at $1.43 billion as of June 30, 2020, with investments in private equity, real estate, natural resources, publicly-traded equities, fixed income securities, and cash.